Acquired partial lipodystrophy; presents usually around 8-10, preceded generally by an acute viral
syndrome
infection; spares legs and hips; 1/3 of patients develop membranoproliferative glomerulonephritis;
associated with accelerated complement activation and a serum immunoglobulin G, called C3
nephritic factor that are felt to cause lysis of adipose tissue.It is named for Luis Barraquer Roviralta and Arthur Simons.
Figure 1.
Facial appearance of patient at 12 years of age showing loss of buccal fat, neck, trunk, and upper extremities' subcutaneous fat.
Figure 2. Facial appearance of patient at 6 years of age.
Figure 3.
Immunofluorescence micrograph from skin biopsy demonstrating granular accumulation of C3 along the basement membrane.
No comments:
Post a Comment