Pallister-Hall syndrome is a disorder that affects the development of many parts of the body. Most people with this condition have extra fingersand/or toes (polydactyly), and the skin between some fingers or toes may be fused (cutaneous syndactyly).An abnormal growth in the brain called a hypothalamic hamartoma is characteristic of this disorder. In many cases, these growths do not cause any medical problems; however, some hypothalamic hamartomas lead to seizures or hormone abnormalities that can be life-threatening in infancy. Other features of Pallister-Hall syndrome include a malformation of the airwaycalled a bifid epiglottis, an obstruction of the anal opening (imperforate anus), and kidney abnormalities. Although the signs and symptoms of this disorder vary from mild to severe, only a small percentage of affected people have serious complications.
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