257. What is Churg-Strauss syndrome ?

Allergic angiitis and granulomatosis involvement in the lung, associated with eosinophilia. Asthma is the cardinal feature (occurs in 95%) and precedes vasculitic phase by 8-10 years; 2/3 of patients have skin lesions which can appear as subcutaneous nodules on extensor surfaces; 70% have P- ANCA; 4/6 following criteria 85% sensitive and 99.7% specific: asthma; eosinophilia>10%; neuropathy; pulmonary opacities; paranasal sinusabnormality; biopsy of blood vessel showing eosinophils in extravasculararea.