Kupffer cells, also known as Browicz-Kupffer cells and stellate macrophages, are specialized macrophages located in the liver lining the walls of the sinusoids that form part of the reticuloendothelial system (RES) (also called mononuclear phagocyte system).
The cells were first observed by Karl Wilhelm von Kupffer in 1876.The scientist called them "Sternzellen" (star cells or hepatic stellate cell) but thought, falsely, that they were an integral part of the endothelium of the liver blood vessels and that they originated from it. In 1898, after several years of research, Tadeusz Browicz, a Polish scientist, identified them, correctly, as macrophages.
The cells were first observed by Karl Wilhelm von Kupffer in 1876.The scientist called them "Sternzellen" (star cells or hepatic stellate cell) but thought, falsely, that they were an integral part of the endothelium of the liver blood vessels and that they originated from it. In 1898, after several years of research, Tadeusz Browicz, a Polish scientist, identified them, correctly, as macrophages.
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